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RECENT TECHNOLOGICAL APPROACHES ON FLOATING DRUG DELIVERY SYSTEM

Abstract : ABSTRACT Latest technological processes has been committed to the improvement of managed launch (CR) dosage forms transport structures to triumph over physiological troubles along with unpredictable gastric emptying times (GRT) and less gastric house instances (GRT). Floating drug delivery device are of specific attraction for deliver pills this is regionally active and have limited absorption window within the stomach and upper part of small gut, displaying low solubility at high pH and drug that is risky in the intestinal or colonic environment. Floating drug shipping systems (FDDS) are substances that go with the flow immediately upon touch with gastric fluids gift within the belly and by using floating drug shipping systems for reinforcing the bioavailability of medicine. The concept of gastric retention comes from the need to localize tablets at a selected target a part of gastrointestinal tract (GIT) which include the belly inside the body. The promising methods, methodologies and technique used within the improvement of FDDS by formulating both effervescent and non-effervescent floating tablets based totally on buoyancy mechanism. By using above suitable promising methods it is viable to supply tablets that have slender therapeutic window at specific area. Keywords: Gastric residence time, Bioavailability, absorption window, swell able polymers

Paper Details : ABSTRACT Latest technological processes has been committed to the improvement of managed launch (CR) dosage forms transport structures to triumph over physiological troubles along with unpredictable gastric emptying times (GRT) and less gastric house instances (GRT). Floating drug delivery device are of specific attraction for deliver pills this is regionally active and have limited absorption window within the stomach and upper part of small gut, displaying low solubility at high pH and drug that is risky in the intestinal or colonic environment. Floating drug shipping systems (FDDS) are substances that go with the flow immediately upon touch with gastric fluids gift within the belly and by using floating drug shipping systems for reinforcing the bioavailability of medicine. The concept of gastric retention comes from the need to localize tablets at a selected target a part of gastrointestinal tract (GIT) which include the belly inside the body. The promising methods, methodologies and technique used within the improvement of FDDS by formulating both effervescent and non-effervescent floating tablets based totally on buoyancy mechanism. By using above suitable promising methods it is viable to supply tablets that have slender therapeutic window at specific area. Keywords: Gastric residence time, Bioavailability, absorption window, swell able polymers

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