Current Issue

An Evaluation of Phytochemicals in Maceration and Infusion Extracts of Cyperusrotundus Linn.Leaves in Two Different Solvents

Neelam Singh and Madhulika Singh

CyperusrotundusLinn.,is a perennial plant also known as purple nutsedge or nutgrass. It is being used as sedative, carminative, stimulant, tonic, aphrodisiac, diuretic, stomachic, anthelmintic, colic remedy and to remove renal calculi. It is reported to beanalgesic, alternative, astringent, antispasmodic, antimicrobial, carminative, contraceptive, demulcent, emmenagogue, emollient, febrifuge, immunostimulant, laxative, stimulative, tonic, and vermifugeproperties. The present work is aimed at extraction and analysis of phytochemicals from the leaves of Cyperusrotundus Linn. in two different methods of phytochemical extraction name maceration and infusion. Differences were observed not only in the yield of extraction but also in the presence of different phytochemical groups.Yield of extraction for acetonic maceration is 0.83%, while that of ethanolic infusion is reported to be 3.27%.Ethanolic extract were found to be rich in carbohydrates, alkaloids, tennins, phenols, flavonoids and saponins. On the other hand the acetonic extracts were rich in presence of alkaloidal group only. Since there has been little work was reported in the phytochemical of leave or areal parts of C. rotundusL., so the present investigation adds the piece of information in phytochemical study of the selected plant for methods and solvents used.

Issue:2, Volume : 1, Page No. 77-84


ESTIMATION OF DIACEREIN USING HYDROTROPIC AGENT AND DYE DRUG REACTION

Kailashpati Pandey, Prabhat Jain and Brijeshkunvar Mishra

This study was designed to develop and validate hydrotropic agent and dye drug reaction methods for estimation of diacerein in capsule formulation. Hydrotropic solubilization is a technique used to increase the aqueous solubility of poorly water-soluble drugs and the present study was aimed at developing a hydrotropic technique to increase the solubility of diacerein. The analysis of tablets indicated good correlation between the amounts estimated and label claim. The study results indicate good sensitivity of the proposed method. The results of analysis were validated statistically and by recovery studies. The developed methods were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was found to be simple, environmentally friendly, accurate and cost effective and can be successfully employed in routine analysis of diacerein in capsule.

Issue:2, Volume : 1, Page No. 85-93


Hepatoprotective effect of ethanolic extract of Curcuma caesia rhizomes in rats on paracetamol induced liver cirrhosis

Rizwan Arif and Sanjay Kumar Dwivedi

The objective of the study to evaluate the hepatoprotective effect of ethanolic extract of Curcuma caesia rhizomes in Wistar rats on paracetamol induced liver. Albino wistar rats were separated into five groups (n=6). Ethanolic extract of Curcuma caesia rhizomes was prepared and evaluated for its hepatoprotective efficacy against paracetamol (PCM) (2g/kg p.o.) induced hepatotoxicity in rats. Silymarin (100mg/kg p.o.) was used as standard. Levels of Serum glutamic pyruvate transaminase (SGPT), Serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), and total protein was evaluated along with histopathological investigation in various experimental groups of rats. Present study suggested thatthe protective effect of ethanolic extract of Curcuma caesia against paracetamol induced hepatic damage.

Issue:2, Volume : 1, Page No. 71-76


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