ABSTRACT Aminopropyloxy derivatives of 1,8-naphthyridines have been synthesized using the principle of Conrad-Limpach synthesis of quinolines. The hydroxy group at 2- position of the naphthyridine ring was converted to the corresponding epoxypropane ether derivative by etherification with epichlorhydrin. The epoxy ether was then aminated in presence of KOH with the corresponding amines to obtain the aminopropyloxy derivatives. The compounds were tested for anti convulsant action at dose of 150mg/Kg relative to diazepam (5mg/Kg) by prevention of PTZ-induced seizures in mice.
Issue:1, Volume : 1, Page No. 1-8 , Brijeshkunvar Mishra
Validated RP-HPLC method for estimation of Etoricoxib & Paracetamol and its applications in analysis of formulations
ABSTRACT The current paper describes a reversed phase high performance liquid chromatographic method for the simultaneous estimation of Etoricoxib and Paracetamol in formulations. The separation was achieved on the LUNA C18 column 5µ (250 x 4.6 mm id), using methanol - water in the ratio 63 - 37 as the mobile phase at 1 ml/min flow rate and 237 nm as detection wavelength. The retention time of Etoricoxib and Paracetamol were 1.6 and 2.9 min respectively. The method was validated in terms of linearity, accuracy, precision, as per ICH Guidelines. The calibration curve was linear in the concentration range from 10-60 µg/ml for etoricoxib and 100-600 µg/ml for paracetamol. Percentage recovery obtained for etoricoxib and paracetamol were 99.60 % and 99.04 % respectively.
Issue:1, Volume : 1, Page No. 9-14 , Prakash Sahu and Shweta Singh
RECENT TECHNOLOGICAL APPROACHES ON FLOATING DRUG DELIVERY SYSTEM
ABSTRACT Latest technological processes has been committed to the improvement of managed launch (CR) dosage forms transport structures to triumph over physiological troubles along with unpredictable gastric emptying times (GRT) and less gastric house instances (GRT). Floating drug delivery device are of specific attraction for deliver pills this is regionally active and have limited absorption window within the stomach and upper part of small gut, displaying low solubility at high pH and drug that is risky in the intestinal or colonic environment. Floating drug shipping systems (FDDS) are substances that go with the flow immediately upon touch with gastric fluids gift within the belly and by using floating drug shipping systems for reinforcing the bioavailability of medicine. The concept of gastric retention comes from the need to localize tablets at a selected target a part of gastrointestinal tract (GIT) which include the belly inside the body. The promising methods, methodologies and technique used within the improvement of FDDS by formulating both effervescent and non-effervescent floating tablets based totally on buoyancy mechanism. By using above suitable promising methods it is viable to supply tablets that have slender therapeutic window at specific area. Keywords: Gastric residence time, Bioavailability, absorption window, swell able polymers
Issue:1, Volume : 1, Page No. 44-60 , Surendra Dangi*, Anup K. Chakraborty, Neeraj Upmanyu, Sanjay K. Dwivedi, Bhaskar Gupta
DESIGN AND OPTIMIZATION OF LAMIVUDINE FLOATING MICROSPHERES
The present study was focused to develop floating microspheres of Lamivudine in order to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption and thereby improved bioavailability. The present study involves preparation and evaluation of floating microspheres using Lamivudine as a model drug for prolongation of the gastric retention time. As Lamivudine is mainly absorbed from stomach, thus using floating microspheres as a mode of drug delivery helps in increasing its residence time and hence increasing the bioavailability of drug. The microspheres were prepared by the Ionic gelation method. The average diameter and surface morphology of the prepared microspheres were characterized by optical microscope and scanning electron microscopic methods respectively. The prepared microspheres were evaluated for particle size, micromeritic study, drug entrapment efficiency, in vitro buoyancy, swelling index and in vitro release. The effect of various formulation variables on the size and drug release was also investigated. All the formulated microspheres were found to possess good flow properties. Scanning electron microscopy confirmed spherical structure of the prepared microspheres. The best formulation F3 drug release kinetics were evaluated using Zero order, First order, Higuchi model, Korsmeyer - Peppas model. After the interpretation of data that was based on the value of a resulting regression coefficient, it was observed that the Korsmeyer- Peppas model has a highest regression coefficient values indicating that the drug release was based on the erosion of polymeric chain matrix system.
Issue:1, Volume : 1, Page No. 15-29 , Pandey G.K., Pandey D., Jain D., Joshi A., Dubey B.K.
Pharmacological Appraisal of Herbal Medicines in treating Hepatic Diseases with Recent Advances: A review
Liver is the most vital organ of the. body, which perform fundamental role in the regulation of diverse processes, such as metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Due to these functions, hepatic diseases continue to arise as main problem for mankind worldwide. Despite advances in modern medicine, there are no completely effective drugs that stimulate hepatic function, that offer complete protection of the organ, or that help to regenerate hepatic cells. The use of natural remedies for the treatement of liver disease has a long history, starting with the Ayurvedic treatement. Among several novel approaches, probiotics, development of a human recombinant single chain antibody and bone marrow transplant based therapy could also be a hope for the treatement of liver diseases in future.
Issue:1, Volume : 1, Page No. 61-70 , Amit Kaushik, Ajay Kumar and Dewasya Pratap Singh
Total phenolic content, flavonoid concentration, antimicrobial and insecticidal screening of aqueous extracts of Annona squamosa (seeds), Azadirachta indica (leaves) and Lavandula angustifolia (flower)
The present study describes the total phenolic content, flavonoid concentration, antimicrobial and insecticidal screening of aqueous extracts of Annona squamosa (seeds), Azadirachta indica (leaves) and Lavandula angustifolia (flower). The total phenolic content in the extracts was determined using Folin-Ciocalteu reagent and their amounts were found to be 0.045, 0.052 and 0.56 mg GA (gallic acid)/mg. The concentrations of flavonoids were found to be 0.98, 1.25 and 1.12 mg Qu (quercetin)/mg. The extract exhibited dose dependent inhibition of test bacteria. Search for natural insecticides, which are easily degradable and do not have any ill effects on the non-target population, remains one of the top priority issues for many countries. In this study, the aqueous extract have exhibited potent insecticidal activity. This finding suggests that Annona squamosa, Azadirachta indica and Lavandula angustifolia may be considered as a natural source of antioxidants and antimicrobial agents.
Issue:1, Volume : 1, Page No. 30-43 , Purva Tiwari, Amit Joshi, B. K. Dubey